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New Pathway To Parkinson's And Alzheimer's Diseases
Although their genetic underpinnings differ, Alzheimer's disease, Parkinson's disease and Huntington's disease are all characterized by the untimely death of brain cells...

Protease Associated With Damage After Stroke Implicated In Huntington's Toxicity
A new study reveals that an enzyme linked with multiple disorders is also involved in the generation of toxic, neuron-killing protein fragments in Huntington's disease (HD). The research, published by Cell Press in the July 29 issue of Neuron, provides insight into Huntington's pathology and proposes new therapeutic strategies for this devastating incurable disease...

Discovery Provides New Hope For Huntington Disease Treatment
Australian scientists have identified the behaviour of the mutant protein 'huntingtin' which leads to the fatal Huntington's disease providing potential targets to treat the disease, a University of Melbourne study reveals. Huntington's disease is a genetic disease with no cure, characterized by a steady decline in motor control and the dysfunction and death of brain cells...

Leap Forward In Efforts To Develop Treatments For Huntington's Disease
Scientists at the Buck Institute for Age Research have discovered that a particular family of enzymes are involved in the breakdown of proteins that modify the production of toxic fragments that lead to the pathology of Huntington's disease...

Huntington's Disease Greatly Underestimated In The UK
The prevalence of Huntington's disease (HD) is substantially underestimated in the UK, with significant implications for those affected, the healthcare system, and research...

UB Researchers Propose A Novel Therapeutic Target For The Treatment Of Huntington's Disease
An article published in The Journal of Biological Chemistry presents a novel pharmacological target that, in combination with a neurotrophic factor, could be used to improve the survival of striatal neurons, the principal nerve cells affected by the neurodegeneration observed in Huntington's disease...

Every Action Has A Beginning And An End (And It's All In Your Brain)
Rui Costa, Principal Investigator of the Champalimaud Neuroscience Programme at the Instituto Gulbenkian de Ciência (Portugal), and Xin Jin, of the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health (USA), describe in the latest issue of the journal Nature, that the activity of certain neurons in the brain can signal the initiation and terminatio...

New PBT2 Data In 2010 Hot Topics Session At International Conference On Alzheimer's Disease
Prana Biotechnology Limited (NASDAQ: PRAN) (ASX: PBT) announced that its Head of Research, Assoc. Prof. Robert Cherny, will present new data on PBT2, the Company's lead compound in development for Alzheimer's disease, at the Hot Topics Therapeutics/Intervention session on July 14th at the International Conference of Alzheimer's Disease (ICAD) in Honolulu...

Prevalence Of Huntington's Disease Much Higher Than Estimated
Huntington's disease (HD) is much more common in the UK than current estimates suggest, according to a new Comment published in the peer-reviewed medical journal The Lancet. The Comment was written by Professor Sir Michael Rawlins, Chairman of the UK National Institute for Health and Clinical Excellence (NICE)...

Abnormal Protein Makes Huntington's Disease Patients Sick
An aggregating protein causes many of the symptoms of Huntington's disease, an incurable and frequently fatal brain disorder. Mosaic winner Ahmad Aziz discovered that the abnormal protein also aggregates in the hypothalamus, the part of the brain that regulates the autonomic nervous system and the endocrine system...

Program Will Use Stem Cell Modeling And Genome Sequencing To Identify And Screen Potential Therapies For Huntington's Disease
The Institute for Systems Biology (ISB) of Seattle, WA, is collaborating with the Gladstone Institute of Neurological Disease (GIND) and its Taube-Koret Center for Huntington's Disease Research to use whole-genome sequencing to identify genes and novel drug targets related to the onset and progression of Huntington's disease (HD)...

Scientists Make Important Step Toward Stopping Plaque-Like Formations In Huntington's Disease
They might not be known for their big brains, but fruit flies are helping to make scientists and doctors smarter about what causes Huntington's disease and how to treat it...

Eventual Huntington's Drug May Have Clear Path To Affected Brain Region, Solomon Snyder Tells Pharmacy Students
If a drug was developed to block a key protein linked to the onset of Huntington's Disease, it could have a clear path to the part of the brain most affected by the disease, while not bothering other parts of the brain and body, said distinguished neuroscientist Solomon H. Snyder, MD, to an audience of about 300 students and faculty at the University of Maryland, Baltimore (UMB)...

Eventual Huntington's Drug May Have Clear Path To Affected Brain Region, Solomon Snyder Tells Pharmacy Students
If a drug was developed to block a key protein linked to the onset of Huntington's Disease, it could have a clear path to the part of the brain most affected by the disease, while not bothering other parts of the brain and body, said distinguished neuroscientist Solomon H. Snyder, MD, to an audience of about 300 students and faculty at the University of Maryland, Baltimore (UMB)...

In Huntington's Disease Ku70 Shown To Be Critical Regulator Of DNA Damage
Ku70, a component of the DNA repair complex, is shown to be a new critical player in the DNA damage-linked pathologies of Huntington's disease (HD), according to a study in the May 3 issue of the Journal of Cell Biology. DNA repair defends against naturally occurring or disease-related DNA damage during the long lifespan of neurons...