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After Stem Cell Transplant For Multiple Myeloma Patients, Lenalidomide Prolongs Disease Control
Multiple myeloma patients are better equipped to halt progression of this blood cancer if treated with lenalidomide, or Revlimid®, following a stem cell transplant, according to a study co-authored by a physician with the Oregon Health & Science University Knight Cancer Institute...
Controlling Inflammation: Novel Drug Candidates Offer New Route
Pursuing a relatively untapped route for regulating the immune system, an international team of researchers has designed and conducted initial tests on molecules that have the potential to treat diseases involving inflammation, such as asthma, rheumatoid arthritis, stroke and sepsis...
New Maintenance Therapy Benefits Patients With Multiple Myeloma
Multiple myeloma is a form of cancer where the plasma cells in the bone marrow grow out of control, causing damage to bones as well as predisposing patients to anemia, infection and kidney failure. A medical procedure called autologous hematopoietic stem cell transplantation, commonly known as a stem cell transplant, is frequently an important treatment option for many patients...
Kidney Donation Hindered By Obesity
Researchers at the Hofstra North Shore-LIJ School of Medicine and Feinstein Institute for Medical Research conducted a retrospective analysis which found that morbid obesity impedes kidney donation...
Problems In Transport Of Donated Human Retina Led Researchers To Discover New Treatment Path For Eye Disease
Sloppy shipping of a donated human retina to an Indiana University researcher studying a leading cause of vision loss has inadvertently helped uncover a previously undetected mechanism causing the disease. The discovery has led researchers to urge review of how millions of dollars are spent investigating the cause of a type of age-related macular degeneration called choroidal neovascularization...
Living Kidney Donors Benefit From New Imaging Protocols
A new study from UCLA shows how magnetic resonance angiography (MRA) and computed tomography angiography (CTA) are equivalent in delineating anatomy in living renal donors. In a study that examined 30 patients and 60 kidneys, both modalities were "excellent" in detecting the number of renal arteries and veins. Dr...
Transplantation Of Fetal Membrane To Prevent Blindness
Transplanting tissue from newborn fetal membranes prevents blindness in patients with a devastating disease called Stevens-Johnson syndrome, a Loyola University Medical Center study has found. The study by senior author Charles Bouchard, MD, and colleagues is published online ahead of print in the journal Cornea...
No Increase In Mortality Rates For Liver Transplants Performed At Night And Weekends
A new study, funded in part by a grant from the National Institutes of Health (NIH), shows that liver transplants performed at night or on weekends do not adversely affect patient or graft survival...
Transplant Recipient Donates Kidney After Disease Threatens The Organ; Re-Implantation Reverses Damage And Allows Another Patient To Thrive
For the first time, a kidney that had been donated to a patient in need was removed and implanted into a new patient, the third individual to have the organ, after it failed in the first transplant recipient...
Animal Model For Xenotransplantation As A Therapy For Type 1 Diabetes
Type1 diabetes is caused by autoimmune destruction of the insulin-producing beta cells. Over 250,000 patients suffer from type 1 diabetes in Germany who are treated with daily insulin injections to maintain glucose metabolism. Replacement of the destroyed beta cells by transplantation of either a complete pancreas organ or isolated human beta cells is the only effective way to cure the disease...
Bioengineered Follicles Grow Hair On Bald Mice
In a proof of concept study for bioengineered organ replacement, researchers in Japan made hair follicles derived from adult stem cells interact with surrounding tissue and show normal hair cycles, when transplanted into the skin of bald mice...
Diabetic Amputations Reduced By Autologous Bone Marrow-Derived Mononuclear Cell Transplants
Autologous (self-donated) mononuclear cells derived from bone marrow (BMMNCs) have been found to significantly induce vascular growth when transplanted into patients with diabetes who are suffering from critical limb ischemia caused by peripheral artery disease (PAD), a complication of diabetes...
Combined, Complimentary Therapies Maximize Neural Stem Cell Transplants For Spinal Cord Injury
Combined, complimentary therapies have the ability to maximize the benefits of neural stem cell (NSC) transplantation for spinal cord repair in rat models, according to a study carried out by a team of Korean researchers who published in a recent issue of Cell Transplantation (20:9), now freely available on-line...
Balancing The Immune System: Discovery Could Aid In The Development Drugs For Organ Transplant, Autoimmune Disorders And Cancer
Loyola researchers are reporting surprising findings about a molecule that helps ramp up the immune system in some cases and suppress it in others. The finding eventually could lead to new drugs to regulate the immune system by, for example, revving it up to attack tumor cells or tamping it down to prevent the rejection of transplanted organs...
Corneal Thickness Linked To Early Stage Fuchs' Endothelial Corneal Dystrophy
A national consortium of researchers has published new findings that could change the standard of practice for those treating Fuchs' Endothelial Corneal Dystrophy (FECD), a disease characterized by cornea swelling that can eventually lead to the need for corneal transplantation...
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