The Cause Identified Of LGL LeukemiaLGL leukemia is a relatively rare, malignant blood disease of the mature T-cells and, in many cases, it is related to autoimmune diseases such as rheumatoid arthritis. The pathogenetic mechanism of the disease has been unknown and it has previously been unclear if the disease is an overreaction of the normal defense system or a malignant hematological disease...
Established Cancer Vaccine Works Better In Tandem With FDA-Approved Kidney Transplant DrugA team from the Perelman School of Medicine and the Abramson Family Cancer Research Institute at the University of Pennsylvania found that the FDA-approved drug daclizumab improved the survival of breast cancer patients taking a cancer vaccine by 30 percent, compared to those patients not taking daclizumab. This proof-of-concept study is published this week in Science Translational Medicine...
Should Children Be Made To Have Vaccines? Two experts discuss in the journal BMJ whether childhood vaccination should be mandatory in the UK. According to Paul Offit, Chief of Infectious diseases at the Children's Hospital of Philadelphia, mandatory vaccination is essential to protect those who are vulnerable from infection...
Potential Breast Cancer Vaccine Combination TherapyA vaccine that targets cancer cells in combination with the drug letrozole, a standard hormonal therapy against breast cancer, significantly increased survival when tested in mice, a team of UC Davis investigators has found. The findings were published in the journal Clinical Cancer Research...
Potential To Treat Arthritis Using Delivery System For Gene TherapyA DNA-covered submicroscopic bead used to deliver genes or drugs directly into cells to treat disease appears to have therapeutic value just by showing up, researchers report. Within a few hours of injecting empty-handed DNA nanoparticles, Georgia Health Sciences University researchers were surprised to see increased expression of an enzyme that calms the immune response...
Controlling Inflammation: Novel Drug Candidates Offer New RoutePursuing a relatively untapped route for regulating the immune system, an international team of researchers has designed and conducted initial tests on molecules that have the potential to treat diseases involving inflammation, such as asthma, rheumatoid arthritis, stroke and sepsis...
During An Injection, Look Away If You Want To Avoid PainHealth professionals commonly say, "Don't look and it won't hurt" before administering an injection, but is there any scientific basis for the advice? A group of German investigators has found that, in fact, your past experience with needle pricks, along with information you receive before an injection, shape your pain experience. Their research is published in the May issue of Pain®...
Medical Device Controls Acute Inflammation, May Prevent SepsisThe body's natural inflammatory response is an essential reaction to injury and infection. When acute inflammation escalates out of control, such as in sepsis, it causes nearly 10% of deaths in the U.S. and more than $17 billion in healthcare costs each year...
Immune System Model Created To Predict Vaccine Efficacy And SafetyVaccine testing and development is an extremely lengthy and complex process that costs billions of dollars every year. In an effort to dramatically improve the speed and success of vaccine research and development, researchers have created an innovative biomimetic model of the human immune system known as the MIMIC® system...
Compounds To Block Immune-Regulating EnzymeScientists at The Scripps Research Institute have found the first chemical compounds that act to block an enzyme that has been linked to inflammatory conditions such as asthma and arthritis, as well as some inflammation-promoted cancers...
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