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Gene Therapy Helps Children With Rare, Incurable Brain Disease
Using gene transfer techniques pioneered by University of Florida faculty, Taiwanese doctors have restored some movement in four children bedridden with a rare, life-threatening neurological disease. The first-in-humans achievement may also be helpful for more common diseases such as Parkinson's that involve nerve cell damage caused by lack of a crucial molecule in brain tissue...
Unravelling How Locomotion Starts
Scientists at the University of Bristol have shed new light on one of the great unanswered questions of neuroscience: how the brain initiates rhythmic movements like walking, running and swimming...
Potential To Predict Parkinson's Disease Via Colonoscopy Or Flexible Sigmoidoscopy
Two studies by neurological researchers at Rush University Medical Center suggest that, in the future, colonic tissue obtained during either colonoscopy or flexible sigmoidoscopy may be used to predict who will develop Parkinson's disease, a neurodegenerative disorder of aging that that leads to progressive deterioration of motor function due to loss of neurons in the brain tha...
Gene Variants Identified That Speed Progression Of Parkinson's Disease
UCLA researchers may have found a key to determining which Parkinson's disease patients will experience a more rapid decline in motor function, sparking hopes for the development of new therapies and helping identify those who could benefit most from early intervention...
Vitamin K2 Potentially Offers Hope For A New Treatment For Parkinson's Disease
Neuroscientist Patrik Verstreken, associated with VIB and KU Leuven, succeeded in undoing the effect of one of the genetic defects that leads to Parkinson's using vitamin K2. His discovery gives hope to Parkinson's patients...
Researchers Discover A New Family Of Key Mitochondrial Proteins For The Function And Viability Of The Brain
This family comprises a cluster of six genes that may be altered in neurological conditions, such as Parkinson's and Charcot-Marie-Tooth disease...
Damaged Stem Cells Commit Suicide For The Good Of The Embryo
Embryonic stem cells - those revered cells that give rise to every cell type in the body - just got another badge of honor. If they suffer damage that makes them a threat to the developing embryo, they swiftly fall on their swords for the greater good, according to a study published online in the journal Molecular Cell...
Researcher Developing Therapy To Halt Symptoms In Parkinson's Patients
Parkinson's disease, a disorder which affects movement and cognition, affects over a million Americans, including actor Michael J. Fox, who first brought it to the attention of many TV-watching Americans. It's characterized by a gradual loss of neurons that produce dopamine...
Once-Marginalized Parkinson's Disease Theory May Be Valid
The March issue of the FEBS Journal reports that scientists from the Californian University in San Diego have discovered new evidence for a theory that was once marginalized with regard to the underlying causes of Parkinson's disease, which conflicts with an older theory that Parkinson's and other neurodegenerative diseases are caused by insoluble intracellular fibrils called amyloids...
Scientists Identify Brain Circuitry Associated With Addictive, Depressive Behaviors
Scientists at the Gladstone Institutes have determined how specific circuitry in the brain controls not only body movement but also motivation and learning, providing new insight into neurodegenerative disorders such as Parkinson's disease - and psychiatric disorders such as addiction and depression...
Parkinson's Disease Neuropsychiatric Features And Fatigue Respond To Transdermal Rotigotine
At the 64th American Academy of Neurology Annual Meeting in New Orleans USA, UCB presented results from their post-hoc analyses of Neupro (rotigotine), which suggests that the drug improves common non-motor symptoms in patients with Parkinson's disease...
Strong Support Uncovered For Once-Marginalized Theory On Parkinson's Disease
University of California, San Diego scientists have used powerful computational tools and laboratory tests to discover new support for a once-marginalized theory about the underlying cause of Parkinson's disease. The new results conflict with an older theory that insoluble intracellular fibrils called amyloids cause Parkinson's disease and other neurodegenerative diseases...
Parkinson's Patients Might Respond To 19th Century Vibration-Chair Therapy
To relieve symptoms of Parkinson's disease, Jean-Martin Charcot, a famous neurologist in the 19th century developed a "vibration chair" that showed improvements in his patients. However, Charcot died soon afterwards, before being able to conduct a more comprehensive evaluation of his therapy...
Vibration Therapy From The 19th Century May Help Today's Parkinson's Patients
In the 19th century, Jean-Martin Charcot, the celebrated neurologist, developed a "vibration chair," to relieve symptoms of Parkinson's disease. Charcot reported improvements in his patients, but he died shortly thereafter and a more complete evaluation of the therapy was never conducted...
Parkinson's Protein Causes Disease Spread In Animal Model
Last year, researchers from the Perelman School of Medicine at the University of Pennsylvania found that small amounts of a misfolded brain protein can be taken up by healthy neurons, replicating within them to cause neurodegeneration...
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