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Stem Cells Show Promise For Delivering Gene Therapy For Huntington's Disease
A team of researchers at the UC Davis Institute for Regenerative Cures has developed a technique for using stem cells to deliver therapy that specifically targets the genetic abnormality found in Huntington's disease, a hereditary brain disorder that causes progressive uncontrolled movements, dementia and death...

Circadian Rhythm Disruption Causes Neurodegeneration, Early Death
New research at Oregon State University provides evidence for the first time that disruption of circadian rhythms - the biological "clocks" found in many animals - can clearly cause accelerated neurodegeneration, loss of motor function and premature death. The study was published in Neurobiology of Disease and done by researchers at OSU and Oregon Health and Science University...

Studies Identify Promising Genes And Small Molecules To Use Against Devastating Diseases
Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis (ALS), cancer, cystic fibrosis and type 2 diabetes. To do its job properly within the cell, a protein first must fold itself into the proper shape...

In Huntington's Disease, Regulatory Enzyme Overexpression May Protect Against Neurodegeneration
Treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease (HD) and other neurodegenerative disorders...

Researchers Slow Progression Of Huntington's Disease In Mouse Models
Working with genetically engineered mice, Johns Hopkins researchers have discovered that a gene (SIRT1) linked to slowing the aging process in cells also appears to dramatically delay the onset of Huntington's disease (HD) and slow the progression of the relentless neurodegenerative disorder...

New Drug That Improves Memory And Prevents Brain Damage In Mice May Prevent Alzheimer's Disease Progression
A new drug candidate may be the first capable of halting the devastating mental decline of Alzheimer's disease, based on the findings of a study published in PLoS one. When given to mice with Alzheimer's, the drug, known as J147, improved memory and prevented brain damage caused by the disease...

Study Identifies Most Effective Ways To Assess Progression In Huntington's Disease, Which Could Speed Up Development Of Disease-modifying Drugs
Researchers have identified a set of objective, validated measures for evaluating new treatments for Huntington's disease (HD) in phase 2 and 3 clinical trials. According to the researchers, whose findings have been published Online first in The Lancet Neurology, the discovery should increase future new drug trial's chances of success to delay onset and reduce the severity of HD...

Newly Established Neuroscience Clinical Trials Center Could Bring Treatments To Patients Faster
In a development that could pave the way for treatment for rare neurological diseases and clues to more common ones, physician-scientists at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center, the University Hospital for Einstein, have secured a grant to establish a clinical site for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT)...

In Mouse Model Dantrolene Protects Neurons From Huntington's Disease
Huntington's disease (HD) is characterized by ongoing destruction of specific neurons within the brain. It affects a person's ability to walk, talk, and think - leading to involuntary movement and loss of muscle co-ordination...

Huntington's Disease - Pridopidine Shows Promise In Trial
According to results of the phase 3 MermaiHD trial published Online First in The Lancet Neurology, a unique drug (pridopidine) that stabilizes dopamine signaling in areas of the brain controlling movement and coordination in patients with Huntington's disease (HD), a condition characterized by an imbalance in the signaling chemical dopamine, seems to be well tolerated and merit...

Protein Form Linked To Huntington's Disease Identified By Gladstone Scientists
Scientists at the Gladstone Institutes have discovered how a form of the protein linked to Huntington's disease influences the timing and severity of its symptoms, offering new avenues for treating not only this disease, but also a variety of similar conditions...

In Mouse Model Of Huntington's Disease, Melatonin Found To Delay Onset, Reduce Deaths
Melatonin, best known for its role in sleep regulation, delayed the onset of symptoms and reduced mortality in a mouse model of Huntington's disease, say researchers at the University of Pittsburgh School of Medicine and Harvard Medical School...

New Insight Into The Cellular Defects In Huntington's Disease
Huntington's disease is a devastating neurogenerative disorder that causes a progressive loss of functional capacity and reduced life span. It is an inherited condition caused by a mutant HTT gene...

Transcriptional Biomarker Identified That Could Help Monitor Huntington's Disease Activity, Evaluate Potential Treatments
Huntington's disease, a devastating genetic disorder that causes degeneration of nerve cells in the brain, affects more than 15,000 Americans, and at least 150,000 are at risk of developing the disease...

Candidate Therapeutic Target Provided By Link Between Aging And Huntington's Disease
Aging is a major risk factor for the progression of neurodegenerative diseases, including Huntington disease (HD). Morris White and colleagues, at Harvard Medical School, Boston, have now determined that modulating levels of the signaling protein Irs2 changes disease progression in a mouse model of HD...