Novel Gene Important For Craniofacial Development Implicated In Facial Cleft Birth DefectsIn the United States, a baby is born with a facial cleft every hour, of every day of the year! Such birth defects result from both gene mutations and environmental insults. PRDM16 is a transcription factor originally described as being aberrantly activated in specific types of leukemia's, and more recently as a master regulator of brown adipose tissue differentiation...
Developing Organisms Can Identify And Fix Facial DefectsDevelopmental biologists at Tufts University have identified a "self-correcting" mechanism by which developing organisms recognize and repair head and facial abnormalities. This is the first time that such a mechanism has been reported for the face and the first time that this kind of flexible, corrective process has been rigorously analyzed through mathematical modeling...
Some Gene Mutations May Be Treatable With DietScientists have moved a step closer to correcting some unhealthy gene mutations with diet, according to a new research report appearing in the April 2012 issue of the journal GENETICS...
Newly Found Protein Helps Cells Build TissuesBrown University biologists have found a new molecule in fruit flies that is key to the information exchange needed to build wings properly. They have also uncovered evidence that an analogous protein may exist in people and may be associated with problems such as cleft lip, or premature ovarian failure...
Risk For Two Birth Defects Affected By Overall Quality Of Pregnant Woman's DietThe overall quality of a pregnant woman's diet is linked with risk for two types of serious birth defects, a new study from the Stanford University School of Medicine has shown. In the study, women who ate better before and during pregnancy gave birth to fewer infants with malformations of the brain and spinal cord, or orofacial clefts, such as cleft lip and cleft palate...
Technology Used To Assess How People View Faces With A Cleft Lip And PalateThe impact of physical attractiveness on social communication is a truth universally acknowledged. It is not surprising, therefore, that individuals with a cleft lip and palate have experienced social isolation and poor self-esteem. But how people really see faces affected by this anomaly has not been studied...
Psychosocial Adjustment Of Adolescents With Cleft Lip And PalateAdolescence is generally viewed as a socially and psychologically challenging period of development. For young people with cleft lip, cleft palate, or both, these challenges can be magnified. How their parents react can add another factor into these children's outlooks...
Migraine, Epilepsy Drug Topamax May Cause Newborn Cleft PalateThe FDA has warned that the drug prescribed for epilepsy named Topamax (topiramate) should not be used by women who are pregnant or plan on childbearing, due to a very high risk of offspring bearing cleft lip and palate defects occuring during the first trimester. Topiramate treats epilepsy in children and adults and was originally marketed as an anticonvulsant...
Dental Procedures For Cleft Lip And Palate Patients Bring Together Function And LooksIt may look the same, but it doesn't chew the same. Different dental treatment options for bilateral cleft lip and palate may result in similar aesthetic appearance, but they produce definite differences in jaw function. People with clefts of the lip and palate often have dental anomalies as well. The number, shape, and position of teeth can be affected...