The Cause Identified Of LGL LeukemiaLGL leukemia is a relatively rare, malignant blood disease of the mature T-cells and, in many cases, it is related to autoimmune diseases such as rheumatoid arthritis. The pathogenetic mechanism of the disease has been unknown and it has previously been unclear if the disease is an overreaction of the normal defense system or a malignant hematological disease...
Predicting Arthritis At Much Earlier Stage With New Biomarker TestMore than 27 million adults currently suffer from osteoarthritis, which is the most common form of arthritis. In the past, doctors have been unable to diagnose patients with arthritis until they begin to show symptoms, which include joint pain and stiffness. By the time these symptoms are present, it is often too late for preventive and minimally invasive treatment options to be effective...
Potential To Treat Arthritis Using Delivery System For Gene TherapyA DNA-covered submicroscopic bead used to deliver genes or drugs directly into cells to treat disease appears to have therapeutic value just by showing up, researchers report. Within a few hours of injecting empty-handed DNA nanoparticles, Georgia Health Sciences University researchers were surprised to see increased expression of an enzyme that calms the immune response...
Compounds To Block Immune-Regulating EnzymeScientists at The Scripps Research Institute have found the first chemical compounds that act to block an enzyme that has been linked to inflammatory conditions such as asthma and arthritis, as well as some inflammation-promoted cancers...
Tiny Organelles Called Primary Cilia Hold The Key To Combat InflammationScientists from Queen Mary, University of London have found a new therapeutic target to combat inflammation. The research, published in the journal Cellular and Molecular Life Sciences, revealed tiny organelles called primary cilia are important for regulating inflammation. The findings could lead to potential therapies for millions of people who suffer from arthritis*...
Juvenile Idiopathic Arthritis Linked To Higher Bacterial Infection Rates According to an observational study published in Arthritis & Rheumatism, children with juvenile idiopathic arthritis (JIA) have higher rates of hospitalized bacterial infection compared with those without JIA. The study demonstrates that the risk of infection in JIA patients was considerably higher with use of high-dose glucocorticoids (steroids)...
Bacterial Infection Rates Higher In Children With Juvenile ArthritisChildren with juvenile idiopathic arthritis (JIA) have higher rates of hospitalized bacterial infection than children without JIA according to an observational study appearing in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR)...
Arthritis - Anxiety Twice As Common As DepressionApproximately one third of adults with arthritis in the USA aged 45+ years suffer from anxiety or depression, researchers from the CDC reported in the journal Arthritis Care & Research. The authors added that the prevalence of anxiety in adults with arthritis is almost twice as high as depression, in spite of more studies focusing on the arthritis-depression link...
Keeping The Immune System Under Control With Stem Cell TherapyA new study, appearing in Cell Stem Cell and led by researchers at the University of Southern California, outlines the specifics of how autoimmune disorders can be controlled by infusions of mesenchymal stem cells. Mesenchymal stem cells (MSC) are highly versatile stem cells that originate from the mesoderm, or middle layer of tissue, in a developing embryo...
Rise In Rheumatoid Arthritis Among Women Fueled By Obesity EpidemicObesity and the painful autoimmune disorder rheumatoid arthritis are each becoming more common, raising a logical question: Could one have something to do with the other? For women, it appears there is a link, Mayo Clinic researchers say. They studied hundreds of patients and found a history of obesity puts women at significant risk of developing rheumatoid arthritis...
Bartonella Infection Associated With Rheumatoid Illnesses In HumansA bacterium historically associated with cat scratch fever and transmitted predominately by fleas may also play a role in human rheumatoid illnesses such as arthritis, according to new research from North Carolina State University. Bartonella is a bacterium that is maintained in nature by fleas, ticks and other biting insects...